Phenotypes Associated with This Genotype

Genotype
MGI:3767044

• Allelic Composition: Chrna4^tm2.1Dra/Chrna4⁺
• Genetic Background: involves: 129S1/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:125305 )

N • mice do not display spontaneous or handling -induced seizures

abnormal behavioral response to addictive substance ( J:125305 )

• in response to injection of 2 mg/kg of nicotine mice display three distinct stereotypic behaviors (saccadic behavior, forelimb dystonia, Straub tail) collectively termed DAC

• the DAC response is not associated with epileptiform changes on electroencephalograms

• Background Sensitivity: on a mixed 129S1/Sv and CD1 background forelimb dystonia and saccadic behavior are more pronounced than in mice on an inbred C57BL/6 background

• on a mixed 129S1/Sv and CD1 background all females and 75% of males display DAC after nicotine injection

• females display more severe forelimb dystonia and Straub tail compared to males

• pretreatment with a low dose of nicotine (0.1 mg/kg) blocks the development of DAC in response to 2 mg/kg nicotine given 10 min later

impaired behavioral response to nicotine ( J:125305 )

• mice display less severe nicotine induced seizures compared to wild-type mice