Phenotypes Associated with This Genotype

Genotype
MGI:3767045

• Allelic Composition: Chrna4^tm2.1Dra/Chrna4⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:125305 )

N • mice do not display spontaneous or handling -induced seizures

abnormal behavioral response to addictive substance ( J:125305 )

• in response to injection of 2 mg/kg of nicotine, mice display three distinct stereotypic behaviors (saccadic behavior, forelimb dystonia, Straub tail) collectively termed DAC

• the DAC response is not associated with epileptiform changes on electroencephalograms

• on a mixed 129S1/Sv, C57BL/6 and CD1 background 94% of females and 89% of males display DAC after nicotine injection

• females display more severe forelimb dystonia compared to males

• pretreatment with a nicotinic channel antagonist does not disrupt the DAC response following injection of 8 mg/kg nicotine but does inhibit seizure responses to this dose of nicotine

• pretreatment with carbamazepine (a sodium channel blocker used to treat autosomal-dominant nocturnal frontal lobe epilepsy) does inhibit the dystonic response to nicotine

impaired behavioral response to nicotine ( J:125305 )

• mice display less severe nicotine induced seizures compared to wild-type mice