Phenotypes Associated with This Genotype

Genotype
MGI:3767046

• Allelic Composition: Chrna4^tm2.1Dra/Chrna4⁺
• Genetic Background: B6.129S1-Chrna4^tm2.1Dra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:125305 )

N • mice do not display spontaneous or handling -induced seizures

abnormal behavioral response to addictive substance ( J:125305 )

• in response to injection of 2 mg/kg of nicotine, mice display three distinct stereotypic behaviors (saccadic behavior, forelimb dystonia, Straub tail) collectively termed DAC

• Background Sensitivity: compared to mice on a mixed 129S1/Sv and CD1 background forelimb dystonia is less severe, manifesting as forelimb suppination with clenched fists and rhythmic forelimb retraction

• Background Sensitivity: compared to mice on a mixed 129S1/Sv and CD1 background saccadic behavior is significantly reduced

• the DAC response is not associated with epileptiform changes on electroencephalograms

impaired behavioral response to nicotine ( J:125305 )

• mice display less severe nicotine induced seizures compared to wild-type mice