Phenotypes Associated with This Genotype

Genotype
MGI:3767188

• Allelic Composition: Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: B6.129P2-Foxg1^tm1(cre)Skm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased forebrain volume ( J:128207 )

• volume of prosencephalon is reduced by 23%

small thalamus ( J:128207 )

• in adult, volume of thalamus is reduced by 21.6%, however at postnatal day 4, volume is not reduced

• total number of cells is reduced in levels 1 and 2 of the ventrobasal complex

abnormal telencephalon morphology ( J:128207 )

decreased striatum size ( J:128207 )

• volume of striatum is reduced by 29.7%

abnormal cerebral hemisphere morphology ( J:128207 )

• length of the medio-lateral and midline anterior-posterior axes of the cerebral hemispheres is reduced

• reduction in dimensions of cerebral hemispheres is observed by postnatal day 4

• area of cortical sheet is reduced at postnatal day 8 and in adult brain

decreased hippocampus volume ( J:128207 )

• volume of hippocampus is reduced by 18.6%

abnormal cerebral cortex morphology ( J:128207 )

• volume of cerebral cortex is reduced by 40.7%

• radial domain of cerebral cortex is substantially disrupted, especially in supragranular layers

• thickness of supragranular layer is reduced by 41.4% although granular and infragranular layers are not reduced

decreased cerebral cortex pyramidal cell number ( J:128207 )

• numbers of large and medium sized neurons are reduced in superficial layers of cortex

thin cerebral cortex ( J:128207 )

• Background Sensitivity: thinning is observed only in C57BL/6 background, not in mixed C57BL/6 and CBA background