Phenotypes Associated with This Genotype

Genotype
MGI:3767630

• Allelic Composition: Bcl11b^tm1Avram/Bcl11b^tm1Avram; Tcra^tm1Mom/Tcra^tm1Mom; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal positive T cell selection ( J:128515 )

• slight increase in the number of apoptotic double positive T cells after 16 hours of culturing, indicating apoptosis is occurring independent of TCR signaling

decreased double-positive T cell number ( J:128515 )

• 2.4 fold reduction in the number of DP T cells in thymus

immune system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal positive T cell selection ( J:128515 )

• slight increase in the number of apoptotic double positive T cells after 16 hours of culturing, indicating apoptosis is occurring independent of TCR signaling

decreased double-positive T cell number ( J:128515 )

• 2.4 fold reduction in the number of DP T cells in thymus

endocrine/exocrine glands

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%