Phenotypes Associated with This Genotype

Genotype
MGI:3769514

• Allelic Composition: Dctn1^tm1Cai/Dctn1^tm1Cai
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:129269 )

embryo

abnormal gastrulation ( J:129269 )

embryonic growth arrest ( J:129269 )

• at E9.5 mice are arrested in development and resemble E8.0 embryos

abnormal neural tube morphology ( J:129269 )

• at E9.5, the neural tube is only partially formed

absent somites ( J:129269 )

nervous system

abnormal neural tube morphology ( J:129269 )

• at E9.5, the neural tube is only partially formed

cellular

increased apoptosis ( J:129269 )

• the number of cells undergoing apoptosis is increased compared to in wild-type mice