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Phenotypes Associated with This Genotype
Genotype
MGI:3769515
Allelic
Composition		 Dctn1tm1Cai/Dctn1+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dctn1tm1Cai mutation (0 available); any Dctn1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
motor neuron degeneration ( J:129269 )
• 12.98+/-0.22 compared to 15.10+/-0.57 in wild-type mice
abnormal neuromuscular synapse morphology ( J:129269 )
• neurofilament and synaptophysin accumulate at neuromuscular junctions unlike in wild-type mice

behavior/neurological
short stride length ( J:129269 )
• at 16 months, 47.98+/-0.85 mm compared to 57.33+/-1.01 mm for wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory