Phenotypes Associated with This Genotype

Genotype
MGI:3769725

• Allelic Composition: Tcf12^tm3Zhu/Tcf12^tm3Zhu; Tcf3^tm4Zhu/Tcf3^tm4Zhu; Tg(Lck-cre)#Zhu/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:129570 )

• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)

• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice

• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells

thymus hypoplasia ( J:129570 )

• thymus cellularity is decreased 20-fold (6.7+/-3.1x10⁶ cells compared to 134.4+/-33.4x10⁶ cells in wild-type thymus)

increased double-negative T cell number ( J:129570 )

• T cell differentiation is blocked at the double negative stage

• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice

• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity

decreased T cell number ( J:129570 )

• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice

decreased double-positive T cell number ( J:129570 )

• mice exhibit less than 1% of the double positive T cells found in wild-type mice

hematopoietic system

increased T cell proliferation ( J:129570 )

• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)

• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice

• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells

thymus hypoplasia ( J:129570 )

• thymus cellularity is decreased 20-fold (6.7+/-3.1x10⁶ cells compared to 134.4+/-33.4x10⁶ cells in wild-type thymus)

increased double-negative T cell number ( J:129570 )

• T cell differentiation is blocked at the double negative stage

• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice

• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity

decreased T cell number ( J:129570 )

• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice

decreased double-positive T cell number ( J:129570 )

• mice exhibit less than 1% of the double positive T cells found in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:129570 )

• thymus cellularity is decreased 20-fold (6.7+/-3.1x10⁶ cells compared to 134.4+/-33.4x10⁶ cells in wild-type thymus)

cellular

increased T cell proliferation ( J:129570 )

• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)

• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice

• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells