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Phenotypes Associated with This Genotype
Genotype
MGI:3769738
Allelic
Composition		 Tcf12tm3Zhu/Tcf12tm3Zhu
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm3Zhu mutation (1 available); any Tcf12 mutation (75 available)
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (43 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:129171 )
• T cells prematurely acquire single positive phenotype compared to in wild-type mice
abnormal CD8-positive, alpha beta T cell morphology ( J:129171 )
• mice present with CD+TCR- T cell population not found in controls

hematopoietic system
abnormal T cell differentiation ( J:129171 )
• T cells prematurely acquire single positive phenotype compared to in wild-type mice
abnormal CD8-positive, alpha beta T cell morphology ( J:129171 )
• mice present with CD+TCR- T cell population not found in controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory