Phenotypes Associated with This Genotype

Genotype
MGI:3770031

• Allelic Composition: Heph^sla/Y
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hypochromic anemia ( J:128474 )

♂ • anemia is most severe at a young age and tends to diminish with increasing age

♂ • iron-dextran injection resolves the anemia

decreased erythrocyte cell number ( J:128474 )

♂ • red blood counts are reduced to about 75% of the wild-type

decreased hematocrit ( J:128474 )

♂

decreased hemoglobin content ( J:128474 )

♂

decreased mean corpuscular hemoglobin ( J:128474 )

♂ • slight reduction in mean corpuscular hemoglobin

decreased mean corpuscular volume ( J:128474 )

♂ • slight reduction in mean cell volume

anisopoikilocytosis ( J:128474 )

♂ • erythrocytes show great variation in size and form

macrocytosis ( J:128474 )

♂ • some cells are macrocytic

microcytosis ( J:128474 )

♂ • many microcytic cells

polychromatophilia ( J:128474 )

♂ • macrocytic cells with marked polychromasia