Phenotypes Associated with This Genotype

Genotype
MGI:3770441

• Allelic Composition: Mapt^tm1(MAPT)Vln/Mapt^tm1(MAPT)Vln
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:129032 )

• in culture, hippocampal cells exhibit less neurite outgrowth than wild-type cells

abnormal hippocampus pyramidal cell morphology ( J:129032 )

• the volume increase in CA1 parallels the increase in CA1 pyramidal cells

enlarged hippocampus ( J:129032 )

• in adult mice, hippocampal volume and neuron number is increased by 20% compared to in wild-type mice

• the volume increase in CA1 parallels the increase in CA1 pyramidal cells

• cells proliferation within the hippocampus is increased

abnormal dendrite morphology ( J:129032 )

• hippocampal cell dendrite length is decreased compared to wild-type

behavior/neurological

enhanced long-term object recognition memory ( J:129032 )

• mice exhibit increased memory retention compared to wild-type mice

decreased anxiety-related response ( J:129032 )

• mice spend more time in the center of an open field test than wild-type mice

cellular

abnormal axon extension ( J:129032 )

• in culture, hippocampal cells exhibit less neurite outgrowth than wild-type cells

increased cell proliferation ( J:129032 )

• when hippocampal cells are grown in culture, proliferation and differentiation into neural phenotypes in greater than in cultures of wild-type cells