Phenotypes Associated with This Genotype

Genotype
MGI:3770615

• Allelic Composition: Dmtf1^tm1Cjs/Dmtf1⁺; Kras^tm2Tyj/Kras⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:126002 )

• mean survival time of double mutants is 41 weeks compared to 55 weeks for Kras^LA+/-, Dmtf1-sufficient mice

neoplasm

increased T cell derived lymphoma incidence ( J:126002 )

• ~30% of mice develop thymic lymphomas

increased skin papilloma incidence ( J:126002 )

• 20-30% of animals develop tail papillomas

increased cholangiocarcinoma incidence ( J:126002 )

• one case of cholangiocarcinoma was observed

abnormal metastatic potential ( J:126002 )

• <5% of animals show distant metastases (liver/intr-abdominal or leg) of lung tumors, while no metastases are observed in Kras^LA+/-, Dmtf1-sufficient mice

increased neurofibroma incidence ( J:126002 )

• one case of neurofibroma was observed

increased osteosarcoma incidence ( J:126002 )

• one case of osteosarcoma was observed

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

decreased tumor latency ( J:126002 )

• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice

integument

increased skin papilloma incidence ( J:126002 )

• 20-30% of animals develop tail papillomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126002 )

• ~30% of mice develop thymic lymphomas

liver/biliary system

increased cholangiocarcinoma incidence ( J:126002 )

• one case of cholangiocarcinoma was observed

skeleton

increased osteosarcoma incidence ( J:126002 )

• one case of osteosarcoma was observed

nervous system

increased neurofibroma incidence ( J:126002 )

• one case of neurofibroma was observed

respiratory system

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size