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Phenotypes Associated with This Genotype
Genotype
MGI:3771394
Allelic
Composition
Stat3tm2Aki/Stat3tm2Aki
Tlr4tm1Aki/Tlr4tm1Aki
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Stat3tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tlr4tm1Aki mutation (7 available); any Tlr4 mutation (92 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• few mice exhibit inflammation characteristic of colitis and symptoms were less severe than in Stat3 null mice
• interferon-gamma production is less than in Stat 3 null mice
• unlike in wild-type mice, LPS fails to induce cytokine production

digestive/alimentary system
• few mice exhibit inflammation characteristic of colitis and symptoms were less severe than in Stat3 null mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory