Phenotypes Associated with This Genotype

Genotype
MGI:3771612

• Allelic Composition: Cfp^tm1Song/Y
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal complement pathway ( J:130108 )

♂ • sera of mice fail to initiate complement by activating C3 in response to LPS from three different bacteria species

♂ • complement activity is restored when sera is pre-mixed with sera from C3^tm1Hrc mice that lack the C3 enzyme

♂ • there is a delayed activation of C3 in mouse sera when low amounts of CVF factor are added

impaired complement alternative pathway ( J:130108 )

♂ • sera fail to initiate complement to LPS and to erthryocytes from mice that lack the complement inhibitor factor Crry (Cr1l^tm1Hmo mice)

♂ • complement induced by yeast wall zymogen is reduced by 1.6-fold

♂ • systemic complement fails to initiate in mice one hour after injection of lipooligosaccharide

♂ • systemic complement is reduced by about 2-fold one hour after injection of LPS

impaired complement classical pathway ( J:130108 )

♂ • antibody-mediated complement of sera is intact as measured by C3 activation in the presence of OVA and anti-OVA immunoglobulins