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Phenotypes Associated with This Genotype
Genotype
MGI:3771614
Allelic
Composition		 Cfbtm1Hrc/Cfbtm1Hrc
Genetic
Background		 involves: 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Hrc mutation (1 available); any Cfb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired complement classical pathway ( J:130108 )
• antibody-mediated complement of sera is severely impaired as measured by C3 activation in the presence of OVA and anti-OVA immunoglobulins
decreased susceptibility to Coronaviridae infection ( J:286325 )
• mice show some protection from intranasal infection with the mouse-adapted SARS-CoV MA15 , showing less weight loss than in wild-type controls, but more weight loss than in C3tm1Crr homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory