Analysis Tools
mortality/aging
|
• mice between 3-9 weeks of age have a 15.8% death rate compared to a 2.2% death rate among littermate controls
|
|
• 45% fewer conditional knockout mice survive to weaning compared to littermate controls
|
hematopoietic system
|
• megakaryocytes derived from femurs show impaired membrane-cytoskeletal association, extending membrane blebs rather than normal sheet-like lamellipodia
|
|
• adult mice have 21% less mean red blood cell count than controls
|
|
• adult mice have 19% less hematocrit in their blood
|
|
• adult mice have 25% less hemoglobin in circulation
|
|
• adult mice have 22% less platelets in their blood though the number is still in the normal range
|
|
• platelets fail to attach to a collagen coated surface compared to control platelets that cover over 70% of the surface area
• the ability of platelets to bind fibrinogen is greatly reduced even in the presence of platelet agonists such as PAR4 peptide
|
digestive/alimentary system
|
• 95% of mice over 8 weeks in age have gastrointestinal bleeding as judged by blood in fecal material
|
cardiovascular system
|
• 95% of mice over 8 weeks in age have gastrointestinal bleeding as judged by blood in fecal material
|
|
• 8% of 1-2 day old mice exhibit bleeding in the peritoneum
|
homeostasis/metabolism
|
• platelets fail to attach to a collagen coated surface compared to control platelets that cover over 70% of the surface area
• the ability of platelets to bind fibrinogen is greatly reduced even in the presence of platelet agonists such as PAR4 peptide
|
|
• does not occur in mice after ferric chloride-induced injury of the common carotid artery
• platelets fail to form thrombi on collagen coated surfaces
|
|
• all mice bleed for at least 10 minutes after a tail cut compared to the mean time of 4.6 minutes that control mice bleed for
|
