Phenotypes Associated with This Genotype

Genotype
MGI:3773039

• Allelic Composition: Trim55^tm1Slbt/Trim55^tm1Slbt
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:130921 )

• heart weight to body weight is increased 8% compared to in wild-type mice

cardiac hypertrophy ( J:130921 )

• 19% of adult mice exhibit cardiac hypertrophy

growth/size/body

increased heart weight ( J:130921 )

• heart weight to body weight is increased 8% compared to in wild-type mice

cardiac hypertrophy ( J:130921 )

• 19% of adult mice exhibit cardiac hypertrophy

immune system

decreased susceptibility to Coronaviridae infection ( J:268979 )

• decreased susceptibility to mouse-adapted SARS coronavirus MA15 infection

• significantly reduced vascular cuffing in the lungs of infected mutant mice compared to controls

• reduced numbers of monocytes, as well as the subset of Ly6C positive monocytes, in lungs of infected mutant mice compared to controls

muscle

increased quadriceps weight ( J:130921 )

• quadriceps weight to body weight is increased 11% compared to in wild-type mice

increased skeletal muscle fiber size ( J:130921 )

• mice exhibit hypertrophy of skeletal muscles and hypertrophy of individual muscle fibers

skeletal muscle hypertrophy ( J:130921 )

• mice exhibit hypertrophy of skeletal muscles and hypertrophy of individual muscle fibers

limbs/digits/tail

increased quadriceps weight ( J:130921 )

• quadriceps weight to body weight is increased 11% compared to in wild-type mice