Phenotypes Associated with This Genotype

Genotype
MGI:3773282

• Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc; Hoxb1^tm1Ipc/Hoxb1^tm1Ipc
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:71033 )

N • patterning of the second pharyngeal arch is normal despite the failure of neural crest cells to migrate into the arch

abnormal neural crest cell migration ( J:71033 )

• neural crest cells emanating from r4 fail to migrate properly and populate the second pharyngeal arch

• however, neural crest cell differentiation, proliferation and apoptosis are normal

abnormal neural crest cell delamination ( J:71033 )

• neural crest cells fail to delaminate from r4

muscle

muscle phenotype ( J:124278 )

N • mice exhibit normal cranial myogenesis

cellular

abnormal neural crest cell migration ( J:71033 )

• neural crest cells emanating from r4 fail to migrate properly and populate the second pharyngeal arch

• however, neural crest cell differentiation, proliferation and apoptosis are normal

abnormal neural crest cell delamination ( J:71033 )

• neural crest cells fail to delaminate from r4