Phenotypes Associated with This Genotype

Genotype
MGI:3774553

• Allelic Composition: Tcf12^tm1Zhu/Tcf12⁺; Tcf3^tm4Zhu/Tcf3^tm4Zhu; Tg(Lck-cre)#Zhu/0
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:75746 )

• there is a developmental block between the double negative and immature single positive stages of T cell development

increased double-negative T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of double negative T cells

increased single-positive T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells

immune system

abnormal T cell differentiation ( J:75746 )

• there is a developmental block between the double negative and immature single positive stages of T cell development

increased double-negative T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of double negative T cells

increased single-positive T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells