Phenotypes Associated with This Genotype

Genotype
MGI:3775288

• Allelic Composition: Notch1^tm2Pst/Notch1^tm2.1Pst
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131563 )

• mice die around E12

embryo

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes and 13 to 17 in Notch1^tm2.1Pst homozygotes

decreased embryo size ( J:131563 )

• at E10.5

abnormal embryonic neuroepithelium morphology ( J:131563 )

• at E10.5

cardiovascular system

abnormal vasculogenesis ( J:131563 )

• at E10.5 mice are anemic due to defects in vasculogenesis

abnormal heart development ( J:131563 )

• at E10.5, mice exhibit an underdeveloped heart loop

nervous system

abnormal embryonic neuroepithelium morphology ( J:131563 )

• at E10.5

hematopoietic system

anemia ( J:131563 )

• at E10.5 mice are anemic due to defects in vasculogenesis

growth/size/body

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes and 13 to 17 in Notch1^tm2.1Pst homozygotes

decreased embryo size ( J:131563 )

• at E10.5