Phenotypes Associated with This Genotype

Genotype
MGI:3775662

• Allelic Composition: Hfe^tm1Wsr/Hfe^tm1Wsr; Tg(Alb1-cre)7Gsc/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased spleen iron level ( J:132134 )

• non-heme splenic iron levels are significantly reduced compared to littermate controls

increased circulating iron level ( J:132134 )

• plasma iron levels are significantly elevated compared to age and sex matched controls

• transferrin saturation is significantly elevated and the unsaturated iron binding capacity is significantly reduced

increased liver iron level ( J:132134 )

• iron accumulates in the parenchymal cells of the liver

• iron levels are 3- to 6- fold higher than littermate controls

hemochromatosis ( J:132134 )

• symptoms in mice are consistent with hemocromatosis

hematopoietic system

decreased spleen iron level ( J:132134 )

• non-heme splenic iron levels are significantly reduced compared to littermate controls

immune system

decreased spleen iron level ( J:132134 )

• non-heme splenic iron levels are significantly reduced compared to littermate controls

liver/biliary system

increased liver iron level ( J:132134 )

• iron accumulates in the parenchymal cells of the liver

• iron levels are 3- to 6- fold higher than littermate controls