Phenotypes Associated with This Genotype

Genotype
MGI:3775795

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Lepr^db/Lepr^db
• Genetic Background: involves: 129P2/OlaHsd * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:103714 )

• higher levels of "advanced glycation end products" in the extracellular matrix

• Ager mRNA levels elevated in the retina

abnormal retina vasculature morphology ( J:103714 )

• significantly higher number of acellular capillaries

• increase of capillary lesions

• increased capillary outpouching indicative of early microaneurysms

cardiovascular system

abnormal retina vasculature morphology ( J:103714 )

• increase of capillary lesions

• significantly higher number of acellular capillaries

• increased capillary outpouching indicative of early microaneurysms