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Phenotypes Associated with This Genotype
Genotype
MGI:3775807
Allelic
Composition		 Fgf10tm1Wss/Fgf10+
Fgfr2tm2Dsn/Fgfr2+
Tg(Pgk1-cre)1Lni/0
Genetic
Background		 involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (33 available)
Fgfr2tm2Dsn mutation (0 available); any Fgfr2 mutation (90 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Submandibular gland is hypoplastic in Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0, Fgf10tm1Wss/Fgf10+, and Fgf10tm1Wss/Fgf10+ Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 mice

endocrine/exocrine glands
abnormal submandibular duct morphology ( J:119849 )
• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant
decreased submandibular gland size ( J:119849 )
• submandibular salivary glands are smaller than either single heterozygous mutant

digestive/alimentary system
abnormal submandibular duct morphology ( J:119849 )
• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant
decreased submandibular gland size ( J:119849 )
• submandibular salivary glands are smaller than either single heterozygous mutant

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory