Phenotypes Associated with This Genotype

Genotype
MGI:3777087

• Allelic Composition: Lrat^tm1.1Bok/Lrat^tm1.1Bok
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

short photoreceptor outer segment ( J:132516 )

• pronounced shortening of the rod outer segment is evident by six weeks of age and persists into adulthood

abnormal eye electrophysiology ( J:132516 )

• there are no detectable electroretinogram (ERG) responses to blue-flash stimuli by dark adapted mice

homeostasis/metabolism

abnormal vitamin A level ( J:132516 )

• levels of all-trans retinyl esters in the retinal pigment epithelium are 9% of that found in control mice

• levels of all-trans retinyl esters are barely detectable in other tissues including liver and lung

nervous system

short photoreceptor outer segment ( J:132516 )

• pronounced shortening of the rod outer segment is evident by six weeks of age and persists into adulthood