Phenotypes Associated with This Genotype

Genotype
MGI:3777283

• Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo
• Genetic Background: B6.129P2-Clnk^tm1Rygo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:131738 )

N • natural killer and natural killer T cell development are normal

increased natural killer cell mediated cytotoxicity ( J:131738 )

• in vitro, natural killer (NK) cells are more efficient at killing YAC-1 cells and produce more IFN-gamma when stimulated with anti-Nk1.1 or Ly49D compared to wild-type NK cells

abnormal NK T cell physiology ( J:131738 )

• stimulated natural killer (NK) T cell produce less IFN-gamma and IL-4 (following CD3 cross-linking or exposure to alpha-GalCer) than stimulated wild-type NK T cells

abnormal interferon-gamma secretion ( J:131738 )

• when stimulated in vitro with anti-Nk1.1 or Ly49D, natural killer (NK) cells produce more IFN-gamma positive cells than when wild-type NK cells are used

• stimulated natural killer (NK) T cell produce less IFN-gamma than stimulated wild-type NK T cells

decreased interleukin-4 secretion ( J:131738 )

• stimulated natural killer (NK) T cell produce less IL-4 than stimulated wild-type NK T cells

hematopoietic system

increased natural killer cell mediated cytotoxicity ( J:131738 )

• in vitro, natural killer (NK) cells are more efficient at killing YAC-1 cells and produce more IFN-gamma when stimulated with anti-Nk1.1 or Ly49D compared to wild-type NK cells

abnormal NK T cell physiology ( J:131738 )

• stimulated natural killer (NK) T cell produce less IFN-gamma and IL-4 (following CD3 cross-linking or exposure to alpha-GalCer) than stimulated wild-type NK T cells