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Phenotypes Associated with This Genotype
Genotype
MGI:3777291
Allelic
Composition		 Clnktm1Rygo/Clnktm1Rygo
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clnktm1Rygo mutation (2 available); any Clnk mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131621 )
N
• natural killer and natural killer T cell development are normal
increased natural killer cell mediated cytotoxicity ( J:131621 )
• natural killer (NK) cells are more efficient at killing EL-4 lymphoma target and BaF/3-Rae1gamma cells than wild-type NK cells
increased interferon-gamma secretion ( J:131621 )
• IFN-gamma production is increased following co-culture with YAC-1 cells

hematopoietic system
increased natural killer cell mediated cytotoxicity ( J:131621 )
• natural killer (NK) cells are more efficient at killing EL-4 lymphoma target and BaF/3-Rae1gamma cells than wild-type NK cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory