Phenotypes Associated with This Genotype

Genotype
MGI:3777767

cx11

• Allelic Composition: H2^b/H2^b; Nfkbid^tm1Clay/Nfkbid^tm1Clay; Rag2^tm1Fwa/Rag2^tm1Fwa; Tg(TcraN15,TcrbN15)L2Elre/?
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

decreased interleukin-2 secretion ( J:132071 )

• lymph node T cells secrete significantly less IL-2 than wild-type T cells in response to irradiated spleen cells loaded with VSV8 antigen

hematopoietic system

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

endocrine/exocrine glands

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

cellular

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells