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Phenotypes Associated with This Genotype
Genotype
MGI:3778619
Allelic
Composition
Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm1Gsc mutation (0 available); any Nr3c1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 20% of mice survive perinatal lethality (J:54931)
• 20% survive to adulthood with no respiratory distress and full fertility (J:81588)
• most mice die at birth
• however, 20% of mice survive
• 80% die shortly after birth of respiratory failure

endocrine/exocrine glands
• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice
• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice
• chromaffin cells exhibit reduced volume density and diameter of granules at E 14.5 and E16.5 compared to wild-type cells
• however, the number of chromaffin cells are normal and NGF-stimulated adrenal chromaffin cells extend neurites normally

homeostasis/metabolism

respiratory system

nervous system
• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice
• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice
• chromaffin cells exhibit reduced volume density and diameter of granules at E 14.5 and E16.5 compared to wild-type cells
• however, the number of chromaffin cells are normal and NGF-stimulated adrenal chromaffin cells extend neurites normally


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory