Phenotypes Associated with This Genotype

Genotype
MGI:3778619

• Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:54931 , J:81588 )

• 20% of mice survive perinatal lethality (J:54931)

• 20% survive to adulthood with no respiratory distress and full fertility (J:81588)

perinatal lethality, incomplete penetrance ( J:54931 )

• most mice die at birth

• however, 20% of mice survive

neonatal lethality, incomplete penetrance ( J:81588 )

• 80% die shortly after birth of respiratory failure

endocrine/exocrine glands

abnormal adrenal chromaffin cell morphology ( J:54931 )

• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice

• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice

• chromaffin cells exhibit reduced volume density and diameter of granules at E 14.5 and E16.5 compared to wild-type cells

• however, the number of chromaffin cells are normal and NGF-stimulated adrenal chromaffin cells extend neurites normally

homeostasis/metabolism

absent circulating adrenaline ( J:54931 )

decreased circulating noradrenaline level ( J:54931 )

respiratory system

respiratory failure ( J:81588 )

nervous system

abnormal adrenal chromaffin cell morphology ( J:54931 )

• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice

• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice

• chromaffin cells exhibit reduced volume density and diameter of granules at E 14.5 and E16.5 compared to wild-type cells

• however, the number of chromaffin cells are normal and NGF-stimulated adrenal chromaffin cells extend neurites normally