Phenotypes Associated with This Genotype

Genotype
MGI:3783260

• Allelic Composition: Gata4^tm1.1Sad/Gata4^tm1.1Sad; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:121367 )

• 30% of cells having Gata4 expression are larger than Gata4-deficient cells in the heart

dilated heart ( J:121367 )

• heart displays dilation, but this is less prominent than if deletion is produced by Tg(Myh7-cre)1Jmk

decreased cardiac muscle contractility ( J:121367 )

• significant reduction of fractional shortening is observed at 24 weeks

muscle

abnormal myocardial fiber morphology ( J:121367 )

• 30% of cells having Gata4 expression are larger than Gata4-deficient cells in the heart

decreased cardiac muscle contractility ( J:121367 )

• significant reduction of fractional shortening is observed at 24 weeks

respiratory system

pulmonary edema ( J:121367 )

• following transverse aortic constriction (TAC), severe pulmonary edema is observed

homeostasis/metabolism

pulmonary edema ( J:121367 )

• following transverse aortic constriction (TAC), severe pulmonary edema is observed