Phenotypes Associated with This Genotype

Genotype
MGI:3783530

• Allelic Composition: Rb1^tm3Tyj/Rb1^tm3Tyj; Tg(Nes-cre)1Atp/0
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit an average lifespan of 107 days and are moribund with pituitary tumors when euthanized

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit pituitary tumors

vision/eye

increased retina apoptosis ( J:91406 )

• mice exhibit increased apoptosis in the retina, especially in the retinal ganglion cell layer compared to wild-type mice

decreased retina photoreceptor cell number ( J:91406 )

• in mice with mosaic cre expression when Tg(Nes-cre)1Mrt is maternally inherited

abnormal retina ganglion layer morphology ( J:91406 )

abnormal retina inner nuclear layer morphology ( J:91406 )

• cell within the inner nuclear cell layer exhibit subtle defects in mice with mosaic cre expression when Tg(Nes-cre)1Mrt is maternally inherited

disorganized retina inner nuclear layer ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit retinal inner nuclear layer disorganization with clusters of ectopic inner nuclear layer cells in the outer plexiform layers approaching the photoreceptors

thin retina outer nuclear layer ( J:91406 )

• in mice with mosaic cre expression when Tg(Nes-cre)1Mrt is maternally inherited

neoplasm

increased pituitary gland tumor incidence ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit pituitary tumors

nervous system

increased pituitary gland tumor incidence ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit pituitary tumors

decreased retina photoreceptor cell number ( J:91406 )

• in mice with mosaic cre expression when Tg(Nes-cre)1Mrt is maternally inherited

reproductive system

transmission ratio distortion ( J:91406 )

• fewer than expected mice are produced with maternal inheritance of Tg(Nes-cre)1Mrt

cellular

increased retina apoptosis ( J:91406 )

• mice exhibit increased apoptosis in the retina, especially in the retinal ganglion cell layer compared to wild-type mice