Phenotypes Associated with This Genotype

Genotype
MGI:3783642

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Tfrc*)Nca}/Gt(ROSA)26Sor^{tm1(Tfrc*)Nca}
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased heart iron level ( J:133221 )

• at 8 weeks of age significant iron loading is seen in the heart unlike wild-type mice or mice homozygous for Hfe^tm2Nca

increased circulating iron level ( J:133221 )

• significant increase in occupancy of serum transferrin with iron without any decrease in iron use for erythropoiesis

increased liver iron level ( J:133221 )

• increase in liver non-heme iron levels, although this increase is less than that in Hfe^tm2Nca

• deposition of iron is predominantly periportal

cardiovascular system

increased heart iron level ( J:133221 )

• at 8 weeks of age significant iron loading is seen in the heart unlike wild-type mice or mice homozygous for Hfe^tm2Nca

liver/biliary system

increased liver iron level ( J:133221 )

• increase in liver non-heme iron levels, although this increase is less than that in Hfe^tm2Nca

• deposition of iron is predominantly periportal