Phenotypes Associated with This Genotype

Genotype
MGI:3783753

• Allelic Composition: Ogg1^tm1Tno/Ogg1^tm1Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA repair ( J:61684 , J:84649 )

• nicking activity toward substrate DNA with 8-OH-G-C pairs is strongly attenuated compared to controls (J:61684)

• mutants exhibit marked accumulation (4.2-fold vs wild-type) of 8-OH-G in their DNA at 9 weeks of age (J:61684)

• mutants treated with renal mutagen and carcinogen KBrO₃ exhibit marked accumulation (26-fold vs treated wild-type) of 8-OH-G in liver DNA between 4 and 12 weeks (J:84649)

• after stopping treatment, levels of 8-OH-G do not decrease as observed in treated controls (J:84649)

homeostasis/metabolism

abnormal DNA repair ( J:61684 , J:84649 )

• nicking activity toward substrate DNA with 8-OH-G-C pairs is strongly attenuated compared to controls (J:61684)

• mutants exhibit marked accumulation (4.2-fold vs wild-type) of 8-OH-G in their DNA at 9 weeks of age (J:61684)

• mutants treated with renal mutagen and carcinogen KBrO₃ exhibit marked accumulation (26-fold vs treated wild-type) of 8-OH-G in liver DNA between 4 and 12 weeks (J:84649)

• after stopping treatment, levels of 8-OH-G do not decrease as observed in treated controls (J:84649)

liver/biliary system

liver/biliary system phenotype ( J:84649 )

N • male mutants treated with KBrO₃ show equivalent cell proliferation and regeneration to wild-type controls with partial hepatectomy 1 week after treatment stoppageJ