Phenotypes Associated with This Genotype

Genotype
MGI:3783754

• Allelic Composition: Ogg1^tm1Tno/Ogg1^tm1Tno; Tg(gptdelta)1Nmi/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:61684 , J:84649 )

• liver DNA from double mutants exhibits more than a 2-fold elevation in spontaneous mutations (single base substitutions) compared to Ogg1-sufficient gpt hemizygotes (J:61684)

• mutation frequency is higher than in Ogg1-wild-type transgenic animals; frequency tends to increase after liver regeneration following partial hepatectomy (J:84649)

• spectrum of mutations in cultured mutant liver cells shows an increase in number transverions (GC->AT) and number of deletion mutations is increased during liver regeneration (J:84649)