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Phenotypes Associated with This Genotype
Genotype
MGI:3783756
Allelic
Composition		 Shhtm6Amc/Shhtm6Amc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shhtm6Amc mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:132152 )
• homozygous mice are still born and show defects consistent with reduced Shh signaling
• neural tube at E10.5 show all Shh-dependent neural progenitor domains resulting in normal induction of floor plate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory
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