Phenotypes for H2 Tg(TcraTcrb)1100Mjb MGI:3783840 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2^b/H2^s Tg(TcraTcrb)1100Mjb/?
Genetic Background	involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (282 available)
H2^s mutation (4 available); any H2 mutation (282 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands

small thymus ( J:133645 )

• the thymus is smaller than normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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