Phenotypes Associated with This Genotype

Genotype
MGI:3783845

• Allelic Composition: Reln^rl-4J/Reln^rl-4J
• Genetic Background: B6.Cg-Reln^rl-4J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:133649 )

• some die by wean age

nervous system

abnormal hippocampus layer morphology ( J:133649 )

• scrambled layering in the cortex with neurons of the hippocampal gyrus scattered in an irregular wavy layer

abnormal stratification in cerebral cortex ( J:133649 )

abnormal cerebellar cortex morphology ( J:133649 )

• the cerebellum is smaller with scrambled Purkinje and granule cells

abnormal cerebellar Purkinje cell layer ( J:133649 )

abnormal cerebellar granule layer morphology ( J:133649 )

small cerebellum ( J:133649 )

behavior/neurological

ataxia ( J:133649 )

• locomotion is impaired by 2 weeks of age, with a leaning side-to-side as they walk and falling onto their sides

impaired balance ( J:133649 )

abnormal gait ( J:133649 )

growth/size/body

decreased body size ( J:133649 )