Phenotypes Associated with This Genotype

Genotype
MGI:3784404

• Allelic Composition: 1700016L21Rik^{Tg(Itgax-HBEGF/EGFP)57Lan}/0
• Genetic Background: C.FVB-1700016L21Rik^{Tg(Itgax-HBEGF/EGFP)57Lan}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:93488 )

• repeated treatment with diphtheria toxin results in lethality due to dendritic cell depletion

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93488 )

• adoptive transfer experiments demonstrate that CD8+ T cell priming with cell-associated antigen does not occur in diphtheria-induced dendritic cell depleted mice

increased neutrophil cell number ( J:194800 )

• neutrophilia is observed in blood after diphtheria toxin treatment, indicating that there is no background effect with respect to C57BL/6

decreased dendritic cell number ( J:93488 )

• CD11c+ (Itgax+) dendritic cells are depleted for 2 days following treatment with diphtheria toxin

decreased CD8-positive, alpha-beta T cell number ( J:93488 )

• treatment with diphtheria toxin results in a substantial loss of CD8+ T cells

decreased cytotoxic T cell cytolysis ( J:93488 )

• in adoptive transfer experiments using diphtheria-induced dendritic cell depleted mice infected with Listeria or malaria at the liver stage

abnormal T cell activation ( J:93488 )

• treatment with diphtheria toxin results in a loss of in vitro stimulation of alloreactive T cells

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:93488 )

• adoptive transfer experiments demonstrate that CD8+ T cell priming with cell-associated antigen does not occur in diphtheria-induced dendritic cell depleted mice

increased neutrophil cell number ( J:194800 )

• neutrophilia is observed in blood after diphtheria toxin treatment, indicating that there is no background effect with respect to C57BL/6

decreased dendritic cell number ( J:93488 )

• CD11c+ (Itgax+) dendritic cells are depleted for 2 days following treatment with diphtheria toxin

decreased CD8-positive, alpha-beta T cell number ( J:93488 )

• treatment with diphtheria toxin results in a substantial loss of CD8+ T cells

decreased cytotoxic T cell cytolysis ( J:93488 )

• in adoptive transfer experiments using diphtheria-induced dendritic cell depleted mice infected with Listeria or malaria at the liver stage

abnormal T cell activation ( J:93488 )

• treatment with diphtheria toxin results in a loss of in vitro stimulation of alloreactive T cells