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Phenotypes Associated with This Genotype
Genotype
MGI:3784427
Allelic
Composition
Tg(Ins2-TFRC/OVA)296Wehi/0
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan mutation (6 available); any 1700016L21Rik mutation (4 available)
Tg(Ins2-TFRC/OVA)296Wehi mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse is absent in pancreatic lymph nodes of dendritic cell depleted mice following treatment with diphtheria toxin regardless of whether mice receive anti-ovalbumin IgG
• however, transfer of dendritic cells into depleted mice restores proliferation

hematopoietic system
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse is absent in pancreatic lymph nodes of dendritic cell depleted mice following treatment with diphtheria toxin regardless of whether mice receive anti-ovalbumin IgG
• however, transfer of dendritic cells into depleted mice restores proliferation

cellular
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse is absent in pancreatic lymph nodes of dendritic cell depleted mice following treatment with diphtheria toxin regardless of whether mice receive anti-ovalbumin IgG
• however, transfer of dendritic cells into depleted mice restores proliferation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory