Phenotypes Associated with This Genotype

Genotype
MGI:3789202

• Allelic Composition: Nos1^tm1Plh/Nos1^tm1Plh; Nos3^tm1Plh/Nos3^tm1Plh
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:100308 )

• 60-80% survival rate at 10 months of age

premature death ( J:100308 )

• about 20-40% die before 10 months of age

reproductive system

reduced fertility ( J:100308 )

• slight reduction in the number of offspring produced from breeding pairs

cardiovascular system

decreased heart rate ( J:100308 )

increased systemic arterial systolic blood pressure ( J:100308 )

homeostasis/metabolism

increased blood osmolality ( J:100308 )

increased blood urea nitrogen level ( J:100308 )

decreased urine sodium level ( J:100308 )

decreased urine osmolality ( J:100308 )

behavior/neurological

polydipsia ( J:100308 )

nervous system

nervous system phenotype ( J:37956 )

N • unlike long term potentiation, long term depression and paired pulse facilitation are not significantly different from controls and no significant abnormalities in hippocampal morphology are detected

abnormal sensory neuron innervation pattern ( J:61144 )

• at P21 the ipsilateral retinocollicular projections are spread across cover more of the medio-lateral axis of and extend further caudally in the superior colliculus rather than being confined to the most medial and rostral regions as in wild-type controls

• at P28, ipsilateral retinocollicular projections remain more broadly distributed in the superior colliculus

• however, by P90 ipsilateral retinocollicular projections resemble those in wild-type controls indicating a delay in refinement rather than a block

reduced long-term potentiation ( J:37956 )

• unlike in either single homozygote, hippocampal long term potentiation is significantly reduced at 1 h after tetanus

• however, long term potentiation in the stratum oriens is not significantly different from controls

renal/urinary system

decreased urine sodium level ( J:100308 )

decreased urine osmolality ( J:100308 )

polyuria ( J:100308 )