Phenotypes Associated with This Genotype

Genotype
MGI:3789298

• Allelic Composition: Lama2^dy-2J/Lama2^dy-2J
• Genetic Background: involves: WK/ReJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:5151 )

• unlike wild-type mice, mice clasp their hindlimbs and alternatively flex and extend their those and legs when suspended by their tails

opisthotonus ( J:5151 )

• mild

hindlimb paralysis ( J:5151 )

• mice drag one hindlimb or the other when walking

muscle

opisthotonus ( J:5151 )

• mild

dystrophic muscle ( J:5151 )

• mice exhibit focal dystrophic lesions such as loss of striation, coagulation necrosis, regenerative activity, variation in fiber size, fibrotic replacement of fibers or increases in connective tissue surrounding muscle fibers, and internal rowing of nuclei

reproductive system

reproductive system phenotype ( J:5151 )

N • unlike Lama2^dy homozygotes, mice reproduce