Phenotypes Associated with This Genotype

Genotype
MGI:3790431

• Allelic Composition: Inha^tm1Bay/Inha^tm1Bay; Smad3^tm1Par/Smad3^tm1Par
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovarian folliculogenesis ( J:125349 )

♀ • oocytes are surrounded by small follicles although follicular development is arrested in a similar manner to mice homozygous for just the Smad3^tm1Par allele

increased ovary tumor incidence ( J:125349 )

♀ • the rapid ovarian tumorigenesis associated with Inha^tm1Bay homozygotes is greatly attenuated when on a Smad3^tm1Par background

♀ • tumorigenesis still occurs as demonstrated by a mass of expansive stromal tissue commonly found on the periphery of the ovary

increased Sertoli cell number ( J:125349 )

♂ • some focal Sertoli cell hyperplasia is present in the testes of two month old mice though no tumors are observed

reproductive system

abnormal ovarian folliculogenesis ( J:125349 )

♀ • oocytes are surrounded by small follicles although follicular development is arrested in a similar manner to mice homozygous for just the Smad3^tm1Par allele

increased ovary tumor incidence ( J:125349 )

♀ • the rapid ovarian tumorigenesis associated with Inha^tm1Bay homozygotes is greatly attenuated when on a Smad3^tm1Par background

♀ • tumorigenesis still occurs as demonstrated by a mass of expansive stromal tissue commonly found on the periphery of the ovary

increased Sertoli cell number ( J:125349 )

♂ • some focal Sertoli cell hyperplasia is present in the testes of two month old mice though no tumors are observed

neoplasm

increased ovary tumor incidence ( J:125349 )

♀ • the rapid ovarian tumorigenesis associated with Inha^tm1Bay homozygotes is greatly attenuated when on a Smad3^tm1Par background

♀ • tumorigenesis still occurs as demonstrated by a mass of expansive stromal tissue commonly found on the periphery of the ovary