Phenotypes Associated with This Genotype

Genotype
MGI:3790432

• Allelic Composition: Inha^tm1Bay/Inha^tm1Bay; Smad3^tm1Par/Smad3⁺
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased adrenal gland tumor incidence ( J:125349 )

• gonadectomy causes adrenal tumorigenesis which is dependent on the chronically elevated gonadotropin levels that result from this manipulation

• the 50% survival rate of female mice with gonadectomies is 37.5 weeks with all mice dying of extensive adrenal tumor burden

• this survival rate is significantly longer than in mice that are homozygote for Inha^tm1Bay but which have two wild-type alleles for Smad3

increased ovary tumor incidence ( J:125349 )

♀ • tumor mass is 50% less than in mice homozygote for Inha^tm1Bay but which have two wild-type alleles for Smad3

reproductive system

increased ovary tumor incidence ( J:125349 )

♀ • tumor mass is 50% less than in mice homozygote for Inha^tm1Bay but which have two wild-type alleles for Smad3

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:125349 )

• gonadectomy causes adrenal tumorigenesis which is dependent on the chronically elevated gonadotropin levels that result from this manipulation

• the 50% survival rate of female mice with gonadectomies is 37.5 weeks with all mice dying of extensive adrenal tumor burden

• this survival rate is significantly longer than in mice that are homozygote for Inha^tm1Bay but which have two wild-type alleles for Smad3

increased ovary tumor incidence ( J:125349 )

♀ • tumor mass is 50% less than in mice homozygote for Inha^tm1Bay but which have two wild-type alleles for Smad3