vision/eye
• hyperpermeable retinal vessels
(J:135279)
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development
(J:135279)
• at P7, retinal vascular density is reduced compared to in wild-type retina
(J:144980)
|
• associated with reduced rate of entry into the cell cycle
(J:101493)
• persists on both a normal chow and low tryptophan diet
(J:146078)
|
homeostasis/metabolism
• when fed a diet containing 75% less tryptophan than normal, circulating serotonin levels are reduced 8- to 10-fold
|
• circulating serotonin levels increase with age
|
skeleton
N |
• despite the decrease in osteoblast numbers in vivo, osteoblast proliferation ex vivo is normal
|
• on a normal diet bone mass is reduced
• when fed a diet containing 75% less tryptophan than normal, bone mass is normalized
|
• variable reduction in mineralization of phalanges at P0, with incomplete penetrance
|
cardiovascular system
• hyperpermeable retinal vessels
(J:135279)
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development
(J:135279)
• at P7, retinal vascular density is reduced compared to in wild-type retina
(J:144980)
|