Phenotypes for Aire H2 MGI:3793704 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Aire^tm1.1Doi/Aire^tm1.1Doi H2^b/H2^b
Genetic Background	NOD.Cg-Aire^tm1.1Doi H2^b/Doi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aire^tm1.1Doi mutation (2 available); any Aire mutation (52 available)
H2^b mutation (28 available); any H2 mutation (282 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

stomach inflammation ( J:107432 )

• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

digestive/alimentary system

stomach inflammation ( J:107432 )

• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

endocrine/exocrine glands

abnormal pancreas physiology ( J:107432 )

• Background Sensitivity: the pancreatitis associated with the Aire^tm1.1Doi allele on the NOD background is absent when the H2^g7 allele is present at homozygocity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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