About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3793733
Allelic
Composition		 Runx1tm3Spe/Runx1tm3Spe
Spi1tm2.1Dgt/Spi1tm2.1Dgt
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Spe mutation (0 available); any Runx1 mutation (32 available)
Spi1tm2.1Dgt mutation (0 available); any Spi1 mutation (27 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymus weight ( J:131217 )
• after pIpC treatment, thymus weight is less than in wild-type mice but greater than in Runx1tm3Spe/Runx1tm3Spe Tg(Mx1-cre)1Cgn mice
increased spleen weight ( J:131217 )
• after pIpC treatment
increased granulocyte number ( J:131217 )
• after pIpC treatment, the number of Gr-1+Mac1+ cells in the spleen is increased 8-fold compared to in wild-type mice
decreased B cell number ( J:131217 )
• after pIpC treatment, the B cell compartment is reduced in the spleen and bone marrow

hematopoietic system
decreased thymus weight ( J:131217 )
• after pIpC treatment, thymus weight is less than in wild-type mice but greater than in Runx1tm3Spe/Runx1tm3Spe Tg(Mx1-cre)1Cgn mice
increased spleen weight ( J:131217 )
• after pIpC treatment
increased granulocyte number ( J:131217 )
• after pIpC treatment, the number of Gr-1+Mac1+ cells in the spleen is increased 8-fold compared to in wild-type mice
decreased B cell number ( J:131217 )
• after pIpC treatment, the B cell compartment is reduced in the spleen and bone marrow

endocrine/exocrine glands
decreased thymus weight ( J:131217 )
• after pIpC treatment, thymus weight is less than in wild-type mice but greater than in Runx1tm3Spe/Runx1tm3Spe Tg(Mx1-cre)1Cgn mice

growth/size/body
increased spleen weight ( J:131217 )
• after pIpC treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory