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Phenotypes Associated with This Genotype
Genotype
MGI:3794729
Allelic
Composition		 Tg(KRT14-Birc5)19Gros/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Birc5)19Gros mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal skin condition ( J:93483 )
• mice exhibit a reduction in sunburn cells associated with UVB-irradiation compared to wild-type mice and Trp53 heterozygotes but do not exhibit as much of a reduction as in Trp53 homozygotes
decreased sensitivity to skin irradiation ( J:93483 )
• mice exhibit a reduction in skin cell apoptosis associated with UVB-irradiation compared to wild-type mice or Trp53 null mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory