Phenotypes Associated with This Genotype

Genotype
MGI:3794731

• Allelic Composition: Hr^hr/Hr^hr; Tg(KRT14-Birc5)19Gros/0
• Genetic Background: involves: C3H * C57BL/6 * SKH1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased squamous cell carcinoma incidence ( J:95011 )

• mice exhibit a doubling of the conversion rate of papillomas to squamous cell carcinomas compared to hairless mice

decreased incidence of tumors by UV induction ( J:95011 )

• following chronic exposure to UVB, tumor burden is reduced 1.5-fold compared to in hairless mice

integument

decreased sensitivity to skin irradiation ( J:95011 )

• mice are 2- to 5-fold more resistant to sunburn cell formation than hairless mice following exposure to UVB

• however, skin differentiation is normal