Phenotypes Associated with This Genotype

Genotype
MGI:3794735

• Allelic Composition: Sftpa1^tm1Kor/Sftpa1^tm1Kor
• Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:35250 )

N • mice do not exhibit any altered lung inflammation

lung inflammation ( J:110382 )

• lung infiltrates are observed 6 hours after exposure to group B streptococcus (GBS) compared to in similarly treated wild-type mice that show infiltrate after 24 hours

• at 48 hours post-infection with GBS, inflammation persists and is more severe than in similarly treated wild-type mice

increased susceptibility to bacterial infection ( J:110382 , J:120552 )

• lung infiltrates are observed 6 hours after exposure to group B streptococcus (GBS) compared to in similarly treated wild-type mice that show infiltrate after 24 hours (J:110382)

• at 48 hours post-infection with GBS, inflammation persists and is more severe than in similarly treated wild-type mice mice exhibit reduced bacterial clearance compared to wild-type mice (J:110382)

• mice exhibit increased systemic infection with GBS compared to wild-type mice with increased splenic burden (J:110382)

• GBS associated with alveolar macrophages is decreased compared to in wild-type mice (J:110382)

• mice exhibit increased susceptibility to infection with Pneumocystis carinii compared to wild-type mice (J:120552)

respiratory system

respiratory system phenotype ( J:35250 )

N • mice do not exhibit any altered lung structure, alveolar phospholipids pool size or composition, or lung inflammation

lung inflammation ( J:110382 )

• lung infiltrates are observed 6 hours after exposure to group B streptococcus (GBS) compared to in similarly treated wild-type mice that show infiltrate after 24 hours

• at 48 hours post-infection with GBS, inflammation persists and is more severe than in similarly treated wild-type mice

abnormal surfactant physiology ( J:111449 )

• surfactant exhibits decreased minimum surface tension and increased sensitivity to plasma inactivation compared to wild-type surfactant

• mice exhibit fewer large aggregates of surfactant compared to in wild-type mice

• the number of large surfactant aggregates following exposure to NMU (N-nitroso-N-methylurea) is decreased compared to in similarly treated wild-type mice