Phenotypes Associated with This Genotype

Genotype
MGI:3794864

• Allelic Composition: Camk4^tm1Tch/Camk4^tm1Tch
• Genetic Background: B6.129X1-Camk4^tm1Tch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:122984 )

• memory for increased vestibuloocular reflex gain is impaired compared to in wild-type mice regardless of spaced training

• however, vestibuloocular reflex, motor function and optokinetic reflex are normal and reduced training stimulus frequency rescues memory of increased vestibuloocular reflex gain

impaired conditioned place preference behavior ( J:108062 )

• mice spend less time exploring the morphine-paired side of the chamber than wild-type mice

• however, initial place preference and withdrawal behaviors are normal

decreased chemically-elicited antinociception ( J:108062 )

• mice exhibit less analgesic tolerance after chronic morphine treatment compared to wild-type mice

skeleton

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice

decreased osteoclast cell number ( J:129599 )

increased bone mineral density ( J:129599 )

increased bone volume ( J:129599 )

• bone volume is increased compared to in wild-type mice

abnormal bone remodeling ( J:129599 )

• LPS-induced bone erosion is reduced compared to in wild-type mice

nervous system

abnormal inhibitory postsynaptic currents ( J:108062 )

• pre-exposure to morphine fails to abolish the morphine-induced decrease in inhibitory postsynaptic current as in wild-type mice

immune system

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice

decreased osteoclast cell number ( J:129599 )

hematopoietic system

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice

decreased osteoclast cell number ( J:129599 )

cellular

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice