Phenotypes Associated with This Genotype

Genotype
MGI:3794989

• Allelic Composition: Rela^tm1.1Gho/Rela^tm1.1Gho
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:134684 )

• most homozygous mice died in utero between 11 and 16 days post-coitum

• most homozygous embryos are normal until 11 days post-coitum, but homozygous embryos recovered after 11dpc exhibited a variety of phenotypes that ranged from normal-looking embryos to embryos that were nearly resorbed at 13.5 dpc

limbs/digits/tail

abnormal limb morphology ( J:134684 )

• some homozygous mice that developed to between 14 and 16 dpc show multiple developmental defects, variable in severity, including deformed limbs

vision/eye

abnormal eye development ( J:134684 )

• a frequently recurring, but variable, abnormal eye development

• rudimentary eyes from homozygous embryos shows formation of the early eye structures, but developmental arrest at various stages

microphthalmia ( J:134684 )

• either bilateral or unilateral with or without anophthalmia

anophthalmia ( J:134684 )

• either bilateral or unilateral with or without microphthalmia